Suggested Duration of Therapy For a given clinical infection: Goal is selection of the right drug, in the right dose for the right period of time. Past traditional treatment durations were based on observational studies, expert opinion, and FDA approved “ goldstandard” regimens. This Table summarizes the duration of therapy suggested for selected common clinical settings. See […]
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Kinetics
Antimicrobial Resistance
Microbes have a variety of mechanisms for resisting antimicrobials. Some mechanisms are intrinsic (naturally produced by the organism), some are induced by certain conditions or drugs, some are genetically acquired mutations, and others can be passed from organism to organism. The last two mechanisms are one reason why preventing the formation of resistant organisms is […]
Diabetic Foot Infections – PEDIS Grades and Treatments
Grade Infection Severity Clinical Manifestations Treatment Location Treatment 1 Uninfected Wound without purulence or inflammation Outpatient Topical antibiotics 2 Mild >2:purlence or erythema, pain, tenderness, warmth, or induration, cellulitis <2cm around ulcer; infection limited to skin/subQ tissue, no complications Mostly Outpatient—Oral 1. Cephalexin 500 mg PO every 6 hours2. Trimethoprim/sulfamethoxazole 2 160 -800 mg tablets PO every […]
Stewardship Intro
There are two main drivers of stewardship in hospitals: IDSA/SHEA Guidelines and the CDC Core Elements.
Intra-Abdominal Infections
Pathogens get more complex as you move down the GI tract: stomach: streptococcus, lactobacilli pancreas (none) bile duct: e.coli, klebsiella, enterococcus small intestines adds diphtheroids distil ileum and colon: bacteroides, clostridium, Enterobacter, E.coli, klebsiella, peptostreptococcus Community-Acquired Intrabdominal Infection: Appendicitis Blood/fluid cultures not routinely needed for patients with community-acquired infection unless clinically toxic or high-risk for […]
The Pros and Cons of Fluoroquinolones
Fluoroquinolones, like Levaquin (levofloxacin) and Cipro (ciprofloxacin), are a popular class of antibiotics that are used to treat a variety of infections. While these antibiotics are highly effective, it’s important to be aware of the pros and cons associated with their use. Patients and providers should have a conversation about these side effects and potential […]
Medications that Can Leave You Chilled and What to Do About It
As the winter months approach, most of us are trying to find ways to stay warm. If you can’t get warm even when you’re all bundled up, it could be your medications. Understanding how medications affect cold tolerance is crucial for maintaining comfort and safety during cold weather. Common Medications That Can Lower Cold Tolerance […]
ID Student Book List
Stewardship Intro Jobs in stewardship Random Kinectics Vanc Gent Timeouts (shorter is better) Tracking Metrics Reportable HAIs Antibiogram Clinical Micro Basic Micro Handout Resistance Vanc/Gent Biostats Study Design/Forest Plots Basic Biostats R Cheat Sheet for Biostats CONSORT Framework? Respiratory CAP and VAP Community MRSA vs Hospital MRSA GI/SSTI/Bone Joint Intra-abdominal Infectious STOP IT C. Diff […]
Surgical Prophylaxis
You must administer surgical prophylaxis at the time of the first incision or as close as possible. Redose if surgery is longer than four hours. No need for post-op, except in cardiac procedures. Usually use cefazolin 2 g (3 g for patients above 120 kg), ceftriaxone, cefotetan, cefoxitin 2 g, clindamycin 900 mg, vancomycin 15 mg/kg Cefazolin 2g is […]