|Prolonged in renal||yes||no||no|
|Prolonged in hepatic||yes||yes||yes|
|T 1/2 in hours||1-4||2-5||2-3|
For allergies and drug testing, I like to remember that codeine is metabolized to morphine, hydrocodone to hydromorphone, and oxycodone to oxymorphone. [it’s a little more complex than that in reality, but these are good to remember].
The presence of morphine in urine can indicate exposure to morphine, heroin, or codeine within 2 to 3 days. Ingestion of bakery products containing poppy seeds can also cause morphine to be excreted in the urine. The presence of hydromorphone greater than 100 ng/mL indicates exposure within 2 to 3 days prior to specimen collection, but could also indicate exposure to hydrocodone. The presence of oxycodone greater than 100 ng/mL indicates exposure to oxycodone within 2 to 3 days prior to specimen collection.