| Morphine | Fentanyl | Hydromorphone | |
| Onset (min) | 5-10 | 1-2 | 5-10 |
| Duration (h) | 2-4 | 1-5 | 2-6 |
| Prolonged in renal | yes | no | no |
| Prolonged in hepatic | yes | yes | yes |
| T 1/2 in hours | 1-4 | 2-5 | 2-3 |
| Active metabolites | yes | no | no |
| Hypotension | yes | no | yes |
| Flushing | yes | no | yes |
| Bronchospasm | yes | no | no |
| Constipation | yes | yes | yes |
Digital PharmD
Informatics in Pharmacy
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