Morphine | Fentanyl | Hydromorphone | |
Onset (min) | 5-10 | 1-2 | 5-10 |
Duration (h) | 2-4 | 1-5 | 2-6 |
Prolonged in renal | yes | no | no |
Prolonged in hepatic | yes | yes | yes |
T 1/2 in hours | 1-4 | 2-5 | 2-3 |
Active metabolites | yes | no | no |
Hypotension | yes | no | yes |
Flushing | yes | no | yes |
Bronchospasm | yes | no | no |
Constipation | yes | yes | yes |