- You must administer surgical prophylaxis at the time of the first incision or as close as possible. Redose if surgery is longer than four hours. No need for post-op, except in cardiac procedures.
- Usually use cefazolin 2 g (3 g for patients above 120 kg), ceftriaxone, cefotetan, cefoxitin 2 g, clindamycin 900 mg, vancomycin 15 mg/kg
- Cefazolin 2g is preferred in most cases, one dose unless surgery > 4 hours or cardiac procedures
- Prophylaxis by surgical procedure
- GI: Cefazolin 2g
- Billary: Cefazolin, cefoxitin, cefotetan or ceftriaxone 2g, or amp/sulbactam 3g
- Appendectomy: cefoxitin or cefotetan 2g or cefazolin + metronidazole (anaerobic coverage)
- Colorectal: cefazolin or ceftriaxone 2g + metronidazole with or without neomycin and erythromycin
- Gynocological: cefazolin, cefoxitin or cefotetan 2g
- Cardiac: cefazolin or cefuroxime 2g
- Orthopedic – cefazolin 2g
- Urologic: None
- Prophylaxis by surgical procedure